Solvent Effects and SN2 and SN1 reactions: Nucleophilic Substitution SN2 reactions and solvent effects Polar aprotic solvents – solvents that do not have acidic proton such as DMSO, DMF, CH3CN, HMPA - accelerate the rate of SN2 reactions by solvating the cation thus making the nucleophile more available to react. On the contrary, protic solvents such as alcohols or amines decrease the rate of SN2 reactions since they tend to solvate nucleophiles (Fig. 1). The partial positive charge that exists in the O-H hydrogens solvate the negative charge of the nucleophile (Nu:-).Solvated nucleophiles are held tightly and are unable to react with the electrophilic substrates – compounds that have leaving group. Fig. 1: Partially positively charged hydrogens from polar O-H bonds solvate partially negative charge of the nucleophile. Solvated nucleophiles – as the one shown above – are unable to react with electrophilic substrates. The effect of solvents on the rate of SN2 nucleophilic substit...